I wanted to come to Chicago. I also wanted to do Saturday Night Live. And then I got to a place where I didn't want to do those things anymore.For the sketch comedy thing, I got cast on MADtv, and that will kill any man's desire to do comedy.

There's also these moments when you're like, oh, I really want to do different things. Not instead of this show [The Big Bang Theory]. It's just a hunger to do something else, too.

Meryl Streep is so brilliant is because she is so human, and aware as a performer.

It's not really about confidence. It's just something that isn't really in the vocabulary of what goes on at work. The writers write and the actors act.

I actually struggled through teaching myself to cook because I'm completely ignorant in the kitchen. So I did really macho things like trying to make my own curry. Really hardcore stuff.

Actually, when I was young, I believe I met Nicolas Cage. I think I was probably eight, and I remember seeing him at somebody's house - it was an event and he happened to be there. People would ask me if I was his son, because I looked like him at that point, so I do remember feeling some connection and just wanting to say, like, 'Papa!'

I always honestly dreamed of coming to Second City in Chicago, although I've never even been there to see a show. But I did a ton of sketch comedy at the Second City in LA, which (at the time, in a different location) wasn't really a theater, it was just a space where you took some classes.

Well, I think that everybody is kind of a nerd at heart.

It's amazing to watch somebody who is kind of this sleazy, degenerate lothario, sex-crazed guy become sort of a romantic, settled-down man about to have a baby.

I came in [MADtv] kind of late in the season. Some of the producers didn't want me but the network did. It was all (messed up) from the beginning.

I was young. I was 23 or 24. I just wasn't a fan of the politics of campaigning - of going into that environment and competing and trying to get into the good graces of the writers.

The weird part is actually, there were so many exceptionally talented people there [ on MADtv]. But it was a disaster. I don't think I enjoyed any of it, really. I had a different sensibility.

I was like, I can't believe I get to be in a scene with Meryl Streep [in Florence Foster Jenkins]! And then I was like, but why do I have to play Chopin? It's already going to be intimidating.

There's no real escape from the work, but in some ways, if you're as obsessive as I am, it's a sweet little thing we've figured out. You bring your work home and you work 24 hours a day, but it's good.