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If there's a seminal discovery in oncology in the last 20 years, it's that idea that cancer genes are often mutated versions of normal genes.
Siddhartha Mukherjee
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Siddhartha Mukherjee
Age: 54
Born: 1970
Born: January 1
Academic
Essayist
Non-Fiction Writer
Oncologist
Physician
Physician Writer
Scientist
New Delhi district
Last
Mutated
Idea
Seminal
Genes
Often
Versions
Ideas
Cancer
Years
Discovery
Normal
Lasts
Oncology
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Good physicians are rarely dispassionate. They agonize and self-doubt over patients.
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This was yet another colonial fascination: to create the conditions of misery in a population, then subject it to social or medical experimentation.
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There is a very moving and ancient connection between cancer and depression.
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I think the way we think about cancer, the way we treat cancer, has dramatically changed in the last century. There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients or providing patients with psychic solace or pain relief.
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In the laboratory, we call this the six-degrees-of-separation-from-cancer rule: you can ask any biological question, no matter how seemingly distant-what makes the heart fail, or why worms age, or even how birds learn songs-and you will end up, in fewer than six genetic steps, connecting with a proto-oncogene or tumor suppressor.
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One swallow is a coincidence, but two swallows make summer.
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I think the cardinal rule of learning to write is learning to read first. I learned to write by learning to read.
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Sandeep Jauhar’s Doctored is a passionate and necessary book that asks difficult questions about the future of medicine. The narrative is gripping, and the writing is marvelous. But it was the gravity of the problem—so movingly told—that grabbed and kept my attention throughout this remarkable work.
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Down to their innate molecular core, cancer cells are hyperactive, survival-endowed, scrappy, fecund, inventive copies of ourselves.
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If the history of medicine is told through the stories of doctors, it is because their contributions stand in place of the more substantive heroism of their patients.
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It was Disney World fused with Cancerland.
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I left Delhi in 1989 and remember very little of how life used to be then. Increasingly, in my recent visits to Delhi, I've started to realize that the city has become intellectually very lively. It makes me want to discover the city over and over again.
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Most days, I go home and I feel rejuvenated. I feel ebullient.
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All cancers are alike but they are alike in a unique way.
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I believe the biggest breakthroughs on cancer could come from brilliant researchers based in India.
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Cancer has enormous diversity and behaves differently: it's highly mutable, the evolutionary principles are very complicated and often its capacity to be constantly mystifying comes as a big challenge.
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Cancer was not disorganized chromosomal chaos. It was organized chromosomal chaos
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It felt—nearly twenty-five hundred years after Hippocrates had naively coined the overarching term karkinos—that modern oncology was hardly any more sophisticated in its taxonomy of cancer.
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I had seen cancer at a more cellular level as a researcher. The first time I entered the cancer ward, my first instinct was to withdraw from what was going on - the complexity, the death. It was a very bleak time.
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Most discoveries even today are a combination of serendipity and of searching.
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