I'm tempted to say that the top three reasons for hopelessness are rejection, rejection, rejection. But let's cast our net wider. 1) Not being able to write as well as we hoped we could. 2) Not being able to write at all. 3) Rejection.

Serious writers write, inspired or not. Over time they discover that routine is a better friend than inspiration.

Writing can be wonderful therapy, and cheap at the price. At the very least, you eventually get bored by thinking about anxious topics and move on.

Anxiety is not only an inevitable part of the writing process but a necessary part. If you’re not scared, you’re not writing.

...wrote Lawrence Block. Someone once told me that fear and courage are like lightning and thunder they both start out at the same time, but the fear travels faster and arrives sooner. If we just wait a moment, the requisite courage will be along shortly. (quoted from Write for Your Live by Lawrence Block)

Be as creative in your tactics as you are in your writing. Find what gets your engine going, no matter how peculiar it may seem to others.