There are clearly people for whom Stoicism immediately clicks, it comes natural, and others for whom it doesn't. Then again, Stoicism isn't the only positive philosophy of life. Buddhism is an excellent alternative, if it speaks more clearly to one's personality or cultural background.

If a theory purports to explain everything, then it is likely not explaining much at all.

I can't speak for others, but I find the fundamental idea that a life worth living is one during which one strives every day to become a better person to be compelling.

... it is because one can build a compelling set of arguments - informed by science and thoroughly compatible with it - that to believe in anything despite the complete lack of evidence is, in fact, irrational.

Death itself is a natural occurrence, it is unavoidable, and the Stoics thought that part of philosophical practice is to get comfortable with the unavoidable, learning to face it with courage.

In my mind, there is no reason why Stoicism shouldn't become as popular as Buddhism, especially in the Western world, where the dominant culture, Christianity, itself absorbed a large number of elements from Greco-Roman Stoicism.

Fate permitting is a standard Stoic phrase meant to remind ourselves that planning things is up to us, but the ultimate outcomes are not under our control. It helps us to develop an attitude of equanimity toward the universe. We should very much try to change things for the better, that's the whole point of the Stoic discipline of action.

The downside of skepticism: it can easily turn into an arrogant position of a priori rejection of any new phenomenon or idea, a position that is as lacking in critical thinking as the one of the true believer, and that simply does not help either science or the public at large.