...Lag...occurred between an initial discovery and its effective clinical application. We analyzed 111 such lags: 8% amounted to 0.1 to 1 year another 18% were 1 to 10 years 17% (lagged) 11-20 years...39% (lagged) 21-50 years only 18% required more than 50 years for application.

Julius H. Comroe, Jr.