In the real world there is no nature vs. nurture argument, only an infinitely complex and moment-by-moment interaction between genetic and environmental effects

The difference between passion and addiction is that between a divine spark and a flame that incinerates.

A long-term substance abuser, a few months before his death, penned this poem: Went downtown, Hastings and Main, looking for relief from the pain. All I did was find a ticket on a one-way train. ... Give me peace before I die. The track is laid out so well we all live our private hell just more tickets on the hell-bound train.

... While nervous tension may be a component of stress, one can be stressed without feeling tension.

Not why the addiction, but why the pain.

Autonomy is impossible as long as one is driven by anything.

A hurt is at the center of all addictive behaviors. . . . The wound may not be as deep and the ache not as excruciating, and it may even be entirely hidden—but it’s there. As we’ll see, the effects of early stress or adverse experiences directly shape both the psychology and the neurobiology of addiction in the brain

We may not be responsible for the world that created our minds, but we can take responsibility for the mind with which we create our world.