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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.

Francis Crick

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Francis Crick
Age: 88 †
Born: 1916
Born: June 8
Died: 2004
Died: July 28
Biochemist
Biologist
Geneticist
Molecular Biologist
Neuroscientist
Physicist
Scientist
University Teacher
Francis Harry Compton Crick
Francis H.C. Crick
Desire
Strongly
Also
Motivated
Many
Rarely
Refute
Related
Molecular
Workers
Suspect
Field
Expressed
Fields
Suspects
Actually
Biology

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Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
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A man who is right every time is not likely to do very much.
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Since I essentially knew nothing, I had an almost completely free choice.
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A busy life is a wasted life.
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Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
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A theory should not attempt to explain all the facts, because some of the facts are wrong
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Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
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It is notoriously difficult to define the word living.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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You can do reverse engineering, but you can’t do reverse hacking.
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This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
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