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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.

Francis Crick

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Francis Crick
Age: 88 †
Born: 1916
Born: June 8
Died: 2004
Died: July 28
Biochemist
Biologist
Geneticist
Molecular Biologist
Neuroscientist
Physicist
Scientist
University Teacher
Francis Harry Compton Crick
Francis H.C. Crick
Problem
Probability
Whole
Closely
Biology
Genes
Central
Related
Synthesis
Science
Gene
Action
Protein

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This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
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God is a hacker, not an engineer
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Again the message to experimentalists is: Be sensible but don't be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
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Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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It seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material.
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Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There's something that might be called the 'graduate student syndrome' graduate students hardly believe they can make a discovery.
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A man who is right every time is not likely to do very much.
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Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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Evolution is cleverer than you are.
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I think she [Rosalind Franklin] was a good experimentalist but certainly not of the first rank. She was simply not in the same class as Eigen or Bragg or Pauling, nor was she as good as Dorothy Hodgkin. She did not even select DNA to study. It was given to her. Her theoretical crystallography was very average.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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