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Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.
Francis Crick
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Francis Crick
Age: 88 †
Born: 1916
Born: June 8
Died: 2004
Died: July 28
Biochemist
Biologist
Geneticist
Molecular Biologist
Neuroscientist
Physicist
Scientist
University Teacher
Francis Harry Compton Crick
Francis H.C. Crick
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Overlap
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Fairly
Two
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Certain
Base
Seems
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More quotes by Francis Crick
There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
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It seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material.
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You’re nothing but a pack of neurons.
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A busy life is a wasted life.
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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It is notoriously difficult to define the word living.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
Francis Crick
Again the message to experimentalists is: Be sensible but don't be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
Francis Crick
Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
Francis Crick
You can do reverse engineering, but you can’t do reverse hacking.
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
Francis Crick
While Occam's razor is a useful tool in the physical sciences, it can be a very dangerous implement in biology. It is thus very rash to use simplicity and elegance as a guide in biological research.
Francis Crick
We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
Francis Crick
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
Francis Crick
The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
Francis Crick
A theory should not attempt to explain all the facts, because some of the facts are wrong
Francis Crick