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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
Francis Crick
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Francis Crick
Age: 88 †
Born: 1916
Born: June 8
Died: 2004
Died: July 28
Biochemist
Biologist
Geneticist
Molecular Biologist
Neuroscientist
Physicist
Scientist
University Teacher
Francis Harry Compton Crick
Francis H.C. Crick
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More quotes by Francis Crick
I think she [Rosalind Franklin] was a good experimentalist but certainly not of the first rank. She was simply not in the same class as Eigen or Bragg or Pauling, nor was she as good as Dorothy Hodgkin. She did not even select DNA to study. It was given to her. Her theoretical crystallography was very average.
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Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
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Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
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Christianity may be OK between consenting adults in private but should not be taught to young children.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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If poly A is added to poly U, to form a double or triple helix, the combination is inactive.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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A theory should not attempt to explain all the facts, because some of the facts are wrong
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There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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Jim and I hit it off immediately, partly because our interests were astonishingly similar and partly, I suspect, because a certain youthful arrogance, a ruthlessness, an impatience with sloppy thinking can naturally to both of us.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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