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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.

Francis Crick

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Francis Crick
Age: 88 †
Born: 1916
Born: June 8
Died: 2004
Died: July 28
Biochemist
Biologist
Geneticist
Molecular Biologist
Neuroscientist
Physicist
Scientist
University Teacher
Francis Harry Compton Crick
Francis H.C. Crick
Method
Genetic
Evidence
Mentioned
Direct
Earlier
Methods
Shown
Opposed
Triplet
Code
Biochemical
Indeed
Indirect

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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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Jim and I hit it off immediately, partly because our interests were astonishingly similar and partly, I suspect, because a certain youthful arrogance, a ruthlessness, an impatience with sloppy thinking can naturally to both of us.
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What could be more foolish than to base one's entire view of life on ideas that, however plausible at the time, now appear to be quite erroneous? And what would be more important than to find our true place in the universe by removing one by one these unfortunate vestiges of earlier beliefs?
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A man who is right every time is not likely to do very much.
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A theory should not attempt to explain all the facts, because some of the facts are wrong
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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The major credit I think Jim and I deserve is for selecting the right problem and sticking to it. It's true that by blundering about we stumbled on gold, but the fact remains that we were looking for gold.
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Again the message to experimentalists is: Be sensible but don't be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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