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Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
Francis Crick
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Francis Crick
Age: 88 †
Born: 1916
Born: June 8
Died: 2004
Died: July 28
Biochemist
Biologist
Geneticist
Molecular Biologist
Neuroscientist
Physicist
Scientist
University Teacher
Francis Harry Compton Crick
Francis H.C. Crick
Determination
Method
Amino
Case
Triplets
Cases
Triplet
Difficult
Unambiguous
Makes
Acid
Much
Methods
Would
Unfortunately
More quotes by Francis Crick
While Occam's razor is a useful tool in the physical sciences, it can be a very dangerous implement in biology. It is thus very rash to use simplicity and elegance as a guide in biological research.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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Since I essentially knew nothing, I had an almost completely free choice.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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A man who is right every time is not likely to do very much.
Francis Crick
Jim and I hit it off immediately, partly because our interests were astonishingly similar and partly, I suspect, because a certain youthful arrogance, a ruthlessness, an impatience with sloppy thinking can naturally to both of us.
Francis Crick
You’re nothing but a pack of neurons.
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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What could be more foolish than to base one's entire view of life on ideas that, however plausible at the time, now appear to be quite erroneous? And what would be more important than to find our true place in the universe by removing one by one these unfortunate vestiges of earlier beliefs?
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If poly A is added to poly U, to form a double or triple helix, the combination is inactive.
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There is no form of prose more difficult to understand and more tedious to read than the average scientific paper.
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Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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Again the message to experimentalists is: Be sensible but don't be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
Francis Crick
Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
Francis Crick
It is one of the more striking generalizations of biochemistry - which surprisingly is hardly ever mentioned in the biochemical textbooks - that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
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We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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