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Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.

Francis Crick

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Francis Crick
Age: 88 †
Born: 1916
Born: June 8
Died: 2004
Died: July 28
Biochemist
Biologist
Geneticist
Molecular Biologist
Neuroscientist
Physicist
Scientist
University Teacher
Francis Harry Compton Crick
Francis H.C. Crick
Case
Triplets
Cases
Triplet
Difficult
Unambiguous
Makes
Acid
Much
Methods
Would
Unfortunately
Determination
Method
Amino

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Again the message to experimentalists is: Be sensible but don't be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
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When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There's something that might be called the 'graduate student syndrome' graduate students hardly believe they can make a discovery.
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Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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The major credit I think Jim and I deserve is for selecting the right problem and sticking to it. It's true that by blundering about we stumbled on gold, but the fact remains that we were looking for gold.
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Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.
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A busy life is a wasted life.
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Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
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There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
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Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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A man who is right every time is not likely to do very much.
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I think she [Rosalind Franklin] was a good experimentalist but certainly not of the first rank. She was simply not in the same class as Eigen or Bragg or Pauling, nor was she as good as Dorothy Hodgkin. She did not even select DNA to study. It was given to her. Her theoretical crystallography was very average.
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