I suspect there's a lot of validity to the premise that big companies aren't going to attract entrepreneurial talent.

Assume the best but hire paranoid people.

User experience is everything. It always has been, but it's undervalued and underinvested in. If you don't know user-centered design, study it. Hire people who know it. Obsess over it. Live and breathe it. Get your whole company on board.

Every major communication tool on the Internet has spam and abuse problems. All email services, blogging services and social networks have to dedicate a significant amount of resources and time to fighting abuse and protecting their users.

When I meet with the founders of a new company, my advice is almost always, ‘Do fewer things.’ It’s true of partnerships, marketing opportunities, anything that’s taking up your time. The vast majority of things are distractions, and very few really matter to your success.

The vast majority of things are distractions, and very few really matter to your success.

Failure of your company is not failure in life. Failure in your relationships is.

News in general doesn't matter most of the time, and most people would be far better off if they spent their time consuming less news and more ideas that have more lasting import.

After high school, I enrolled at the University of Nebraska at Lincoln, but I stayed only a year and a half. I felt college was a waste of time I wanted to start working.

I tried to be a ski bum when I stepped away from Twitter, and I wasn't a very good skier.

When you’re obsessing about one thing, you can reach insights about how to solve hard problems. If you have too many things to think about, you’ll get to the superficial solution, not the brilliant one.