We usually don't have applications in mind. They come later.

By the time I entered college, I had decided not to have children, a decision that was never regretted. Accordingly, I was careful to court only girls who wanted to have professional careers.

I have always felt that I understood a phenomenon only to the extent that I could visualise it. Much of the charm organic chemical research has for me derives from structural formulae. When reading chemical journals, I look for formulae first.

Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired.

This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail.