We usually don't have applications in mind. They come later.

By the time I entered college, I had decided not to have children, a decision that was never regretted. Accordingly, I was careful to court only girls who wanted to have professional careers.

This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail.

I have always felt that I understood a phenomenon only to the extent that I could visualise it. Much of the charm organic chemical research has for me derives from structural formulae. When reading chemical journals, I look for formulae first.

Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired.