What is the thing that matters most to making progress right now?

Managing by trying to be liked is the path to ruin.

If there's ever an example of the importance of making bold bets and focusing on what you love, it's Twitter.

People have Plato's form in their mind of what a leader is, or what a C.E.O. is, and it is a bunch of elements that I really don't conform to at all. I've given this a lot of thought, and I came to the conclusion that I don't care.

The key is to just get on the bike, and the key to getting on the bike… is to stop thinking about ‘there are a bunch of reasons I might fall off’ and just hop on and peddle the damned thing. You can pick up a map, a tire pump, and better footwear along the way.

Believe that if you make courageous choices, and bet on yourself, then you will have an impact.

The Internet destroyed most of the barriers to publication. The cost of being a publisher dropped to almost zero with two interesting immediate results: anybody can publish, and more importantly, you can publish whatever you want.

I was in Shanghai recently, where Twitter is blocked, and yet there were ads and billboards across town with hashtags on them.

Twitter brings you closer. I mean, we see this over and over again from our users. It brings them closer to the action. It brings them closer to their heroes.

Successful businesses measure and count things. I think that's a safe assumption on top of which we can drop the following hypothesis: unsuccessful business either measure nothing, the wrong things, too many things, or finally, they measure the right things but they don't communicate the measurements efficiently.

Twitter is a global town square.

Don't always worry what your next line is going to be.

That’s just silly. Closing a global business in reaction to single-issue national politics is foolish.

Not only can you not plan the impact you're going to have, you often won't recognize it when you're having it.

Apple is our mentor, Facebook is our enemy.

When you are doing what you love to do, you become resilient.