Well, in pharmacology, if the effect is local, it's of course absolutely awkward to use it in any other way than as a local treatment.

Thinking is movement confined to the brain

In Sweden, water fluoridation, to my knowledge, is no longer advocated by anybody. In Sweden, the emphasis nowadays is to keep the environment as clean as possible with regard to pharmacologically active and, thus, potentially toxic substances.

Fluorine has a protecting action against caries, but this is a local effect. If you drink it, you are running the risk of all kinds of toxic actions.

It is my sincere hope that Christopher Bryson's apparently thorough and comprehensive perusal of the scientific literature on the biological actions of fluoride and the ensuing debates through the years will receive the attention it deserves and that its implications will be seriously considered.

Ann Sjoerdsma has successfully blended the fascinating story of her illustrious father's scientific achievements [in wide-ranging] drug research, with an enjoyable historic account of the astounding progress of biomedical science during the second half of the 20th century.

Sweden rejected fluoridation in the 1970s, and in this excellent book these three scientists have confirmed the wisdom of that decision. Our children have not suffered greater tooth decay, as World Health Organization figures attest, and in turn our citizens have not borne the other hazards fluoride may cause

In modern pharmacology it's so clear that even if you have a fixed dose of a drug, the individuals respond very differently to one and the same dose.