I play with microbes. There are, of course, many rules to this play...but when you have acquired knowledge and experience it is very pleasant to break the rules and to be able to find something nobody has thought of.

One sometimes finds what one is not looking for. When I woke up just after dawn on Sept. 28, 1928, I certainly didn’t plan to revolutionize all medicine by discovering the world’s first antibiotic, or bacteria killer. But I guess that was exactly what I did.

It is the lone worker who makes the first advance in a subject: the details may be worked out by a team, but the prime idea is due to the enterprise, thought, and perception of an individual.

Nature makes penicillin I just found it.

Suggested remedy for the common cold: A good gulp of whiskey at bedtime-it's not very scientific, but it helps.

One sometimes finds what one is not looking for.

Penicillin sat on a shelf for ten years while I was called a quack.

Penicillin cures, but wine makes people happy.

If penicillin can cure those that are ill, Spanish sherry can bring the dead back to life.

The unprepared mind cannot see the outstretched hand of opportunity.

For the birth of something new, there has to be a happening. Newton saw an apple fall James Watt watched a kettle boil Roentgen fogged some photographic plates. And these people knew enough to translate ordinary happenings into something new.

It was astonishing that for some considerable distance around the mould growth the staphococcal colonies were undergoing lysis. What had formerly been a well-grown colony was now a faint shadow of its former self...I was sufficiently interested to pursue the subject.

(The discovery of penicillin) was a triumph of accident, a fortunate occurrence which happened while I was working on a purely academic bacteriological problem.